Open AccessAcute low frequency dorsal subthalamic nucleus stimulation improves verbal fluency in Parkinson's disease
Author(s) -
Darrin J. Lee,
Neil M. Drummond,
Utpal Saha,
Philippe De Vloo,
Robert F. Dallapiazza,
Robert Gramer,
Tameem M. AlOzzi,
Jordan Lam,
Aaron Loh,
Gavin J.B. Elias,
Alexandre Boutet,
Jürgen Germann,
Mojgan Hodaie,
Alfonso Fasano,
Renato P. Munhoz,
William D. Hutchison,
Mélanie Cohn,
Robert Chen,
Suneil K. Kalia,
Andrés M. Lozano
Publication year - 2021
Publication title -
brain stimulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.685
H-Index - 81
eISSN - 1935-861X
pISSN - 1876-4754
DOI - 10.1016/j.brs.2021.04.016
Subject(s) - verbal fluency test , stimulation , subthalamic nucleus , deep brain stimulation , psychology , neuroscience , audiology , cognition , fluency , parkinson's disease , medicine , disease , neuropsychology , mathematics education
Parkinson's disease (PD) is a common neurodegenerative disorder that results in movement-related dysfunction and has variable cognitive impairment. Deep brain stimulation (DBS) of the dorsal subthalamic nucleus (STN) has been shown to be effective in improving motor symptoms; however, cognitive impairment is often unchanged, and in some cases, worsened particularly on tasks of verbal fluency. Traditional DBS strategies use high frequency gamma stimulation for motor symptoms (∼130 Hz), but there is evidence that low frequency theta oscillations (5-12 Hz) are important in cognition.
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