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13 Subcortical band heterotopia (SBH), also known as doublecortex syndrome,is a 14 malformation of cortical development resulting from mutations in thedoublecortin gene 15 (DCX). It is characterized by a lack of migration ofcortical neurons that accumulate in the 16 white matter forming a heterotopicband. Patients with SBH may present mild to moderate 17 intellectual disabilityas well as epilepsy. The SBH condition can be modeled in rats by in 18 uteroknockdown (KD) of Dcx. The affected cells form an SBH reminiscent of thatobserved in 19 human patients and the animals develop a chronic epilepticcondition in adulthood. Here, 20 we investigated if the presence of an SBH issufficient to induce cognitive impairment in 21

Spared cognitive and behavioral functions prior to epilepsy onset in a rat model of 2 subcortical band heteropia