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Peptide Nucleic Acids (PNA) are non-natural oligonucleotides mimics.{\gamma}-PNA backbone are formed by standard nucleic acids nucleobasesconnected by a neutral N-(2-aminoethyl)glycine backbone linked by a peptidebond. In this study, we use Nuclear Magnetic Resonance (NMR) and CircularDichroism (CD) to explore the properties of the supramolecular duplexes formedby these species. We show that standard Watson-Crick base pair as well asnon-standard ones are formed in solution. The duplexes thus formed presentmarked melting transition temperatures substantially higher than their nucleicacid homologs. Moreover, the presence of a chiral group on the{\gamma}-peptidic backbone increases further more this transition temperature,leading to very stable duplexes.

Duplex formation and secondary structure of {\gamma}-PNA observed by NMR and CD