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Management of highly antiretroviral therapy (ART)experienced patients continues to be a challenge, and there are scarce “real-world” data about their long-term virologic and immunologic responses. Darunavir/ritonavir (DRV/r) was included among the antiretroviral drugs available in Brazil in 2008. Since then five Brazilian studies evaluated the effectiveness of salvage therapy, most of them DRV/rbased. In 2013, we published in this journal a single center prospective cohort study where 82.6% of patients achieved HIV RNA <50 copies/mL after 48 weeks of treatment.1 Other four Brazilian retrospective observational studies were published showing 74.7–84% of patients with HIV RNA <50 copies/mL. Follow-up in all these studies was also limited to 48 weeks.2–5 Herein, we report the results alongside seven years of our cohort in São Paulo. In line with the original report, non-completers were considered as failures in the analysis of virologic response. In 2016, seven years after

the brazilian journal of infectious diseases

Long-term virologic and immunologic responses on darunavir/ritonavir – containing regimens among highly antiretroviral therapy-experienced patients: 7-year follow-up of a prospective cohort study in São Paulo, Brazil