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Philadelphia chromosome-negative myeloproliferative neo-plasms (MPNs), including essential thrombocythemia (ET),polycythemia vera (PV) and primary myelobrosis (PMF),are characterized by excessive myeloid proliferation, withpredominant megakaryocytic, erythroid, and megakary-ocytic/granulocytic expansion, respectively, and have apotential of transformation to acute myeloid leukemia.

Reactive oxygen species overload promotes apoptosis in JAK2V617F-positive cell lines