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An 82-year-old male presented with dysphagia to solids and liquids, weight loss, odynophagia and left cervical pain for two months. Fever or night sweats were not reported. An otorhinolaryngological examination revealed permeable nostrils, free cavum, erythema of the arytenoid mucosa, and a suspicion of a malignant lesion in the left arytenoepiglottic fold. No lymphadenopathy of significant size was palpable. Biopsy showed neoplastic cells with positive immunohistochemical pattern for LCA, Bcl-2, Bcl-6, Epstein–Barr virus (EBV), CD5, CD30, CD10, cyclin D1 and MUM1, allowing the diagnosis of diffuse large B-cell lymphoma of germinal center origin. Moderately high Ki-67 labeling (60%) indicated a malignant nature of the tumor.

Supraglottic primary B-cell lymphoma by fluorine-18 fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG-PET/CT)