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In this article we compare electrical conductance events from single channelrecordings of three TRP channel proteins (TRPA1, TRPM2 and TRPM8) expressed inhuman embryonic kidney cells with channel events recorded on synthetic lipidmembranes close to melting transitions. Ion channels from the TRP family areinvolved in a variety of sensory processes including thermo- andmechano-reception. Synthetic lipid membranes close to phase transitions displaychannel-like events that respond to stimuli related to changes in intensivethermodynamic variables such as pressure and temperature. TRP channel activityis characterized by typical patterns of current events dependent on the type ofprotein expressed. Synthetic lipid bilayers show a wide spectrum of electricalphenomena that are considered typical for the activity of protein ion channels.We find unitary currents, burst behavior, flickering, multistep-conductances,and spikes behavior in both preparations. Moreover, we report conductances andlifetimes for lipid channels as described for protein channels. Non-linear andasymmetric current-voltage relationships are seen in both systems. Withoutfurther knowledge of the recording conditions, no easy decision can be madewhether short current traces originate from a channel protein or from a purelipid membrane

Comparing ion conductance recordings of synthetic lipid bilayers with cell membranes containing TRP channels