Open AccessBis-Hydrazonoyl chloride as precursors for synthesis of novel polysubstituted bis-azoles
Author(s) -
Nabila A. Kheder,
Thoraya A. Farghaly
Publication year - 2013
Publication title -
arabian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.789
H-Index - 70
eISSN - 1878-5379
pISSN - 1878-5352
DOI - 10.1016/j.arabjc.2013.11.040
Subject(s) - chemistry , benzimidazole , pyrazole , antimicrobial , combinatorial chemistry , chloride , proton nmr , triazole , stereochemistry , organic chemistry
A series of novel bis-pyrazole, bis(imidazo[1,2-b][1,2,4]triazole) and bis(imidazo[1,2-a]benzimidazole) derivatives were synthesized via bis-hydrazonoyl chloride. Structures of the synthesized compounds were elucidated by means of IR, 1H NMR and mass spectral data. The biological activity of the newly synthesized compounds was examined and some of them were found to possess antimicrobial and anticancer activities
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