English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Open

Presents the pdf analysis as premium feature

PDF Analysis

Insights

Presents the summarisation as premium feature

Summarisation

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

A clinical practice-based observational study was performed to compare the outcome of alendronate (ALN) and teriparatide (TPTD) treatment among Japanese postmenopausal women with a history of fragility fractures. Sixty-one Japanese postmenopausal women with a history of fragility fractures were treated with ALN (35 mg weekly, n = 32) or TPTD (20 μg daily, n = 29) for 2 years in our outpatient clinic. Alfacalcidol (1 μg daily) was combined with ALN. The lumbar spine or total hip bone mineral density (BMD) was measured using dual energy X-ray absorptiometry, and bone turnover markers were monitored. ALN decreased the urinary levels of cross-linked N-terminal telopeptides of type I collagen (NTX) (38.3% after 3 months) and the serum levels of alkaline phosphatase (ALP) (25.7% at 24 months), whereas TPTD increased the serum levels of intact procollagen type 1 N-terminal propeptide (P1NP) and ALP (79% and 14.1%, respectively at 24 months). Both ALN and TPTD increased the lumbar spine BMD (8.8% and 15.9%, respectively) and sustained the total hip BMD at 24 months. One patient treated with ALN experienced vertebral fractures, and one patient treated with TPTD experienced a nonvertebral fracture. These results confirmed the differential effects of ALN and TPTD on bone turnover and the greater effect of TPTD on the BMD among Japanese postmenopausal women with a history of fragility fractures

osteoporosis and sarcopenia

Comparative effect of alendronate and teriparatide on bone mineral density and bone turnover among Japanese postmenopausal women with history of fragility fractures: A clinical practice-based observational study