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Radiation-induced interstitial pneumonitis (IP) is a rare but possibly severe toxicity after radiation therapy (RT) in patients with comorbidities treated for breast cancer. Minimal symptoms are generally seen in the majority of patients and are resolved with short-term steroid administration. Since the introduction of treatment planning based on 3-dimensional conformal RT, IP risk has been significantly reduced with the application of rigorous lung constraints. With the use of modern techniques and hypofractionation, <2% of patients have experienced IP symptoms after a median follow-up of 15 months with ipsilateral lung V30 as the most relevant dosimetric predictor for IP risk. However, dose delivered to the ipsilateral lung, comorbidities, and virus infection could change the outcome of patients infected by Coronavirus Disease 2019 (COVID-19) during RT. In this report, we describe a 73-year-old woman with a severe COVID-19 pneumonia infection diagnosed during RT for breast cancer. The main comorbidities were

Regional Lymph Node Irradiation in Breast Cancer May Worsen Lung Damage in Coronavirus Disease 2019 Positive Patients