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Summary  There is risk of mandibular osteoradionecrosis following external radiotherapy to tumors at the base of the tongue. To date, no report evaluates sparing of the mandibular bone offered by use of spacers. Here, we introduce and evaluate a custom-made mouthpiece employing a spacer for reduction of osteonecrosis following carbon-ion radiotherapy of tongue base tumors.

The Efficacy of a Custom-Made Mouthpiece With Spacer to Reduce Osteoradionecrosis in Carbon-Ion Radiation Therapy for Tongue-Base Tumor