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Pulmonary extramedullary hematopoiesis, either in the lung parenchyma or the pleura, is an unusual sequela of marrow-depleting disorders that can precipitate symptomatic compromise of the respiratory system. In case reports of patients with pulmonary extramedullary hematopoiesis, low-dose external beam radiation therapy that targets the lungs has been shown to palliate respiratory symptoms and control pulmonary extramedullary hematopoiesis– associated pleural effusions with mixed results. Here, we present a case of symptomatic bilateral pulmonary extramedullary hematopoiesis-associated pleural effusions that were effectively managed with low-dose radiation therapy. The patient provided written consent to report the details of her case, including the use of images.

advances in radiation oncology

Complete response of pleural effusions caused by extramedullary hematopoiesis to low-dose, single fraction palliative radiation therapy: Case report and literature review