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The purpose of this work was to use magnetic resonance imaging (MRI) of hyperpolarized (HP) 129 Xe dissolved in pulmonary tissue (PT) and red blood cells (RBCs) to detect regional changes to PT structure and perfusion in a partial-lung rat model of radiation-induced lung injury and compare with histology.

advances in radiation oncology

Detection of regional radiation-induced lung injury using hyperpolarized 129 Xe chemical shift imaging in a rat model involving partial lung irradiation: Proof-of-concept demonstration