English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

A 59-year-old woman consulted with a 2-year history of burning erythematous lesions on her tongue. Physical examination revealed glossitis, papillary atrophy, and erythematous macules on the dorsum and lateral borders (Fig. 1), hard palate, and oral mucosa. Histopathology revealed an inflammatory infiltrate with eosinophils and vascular congestion. Immunofluorescence was negative. Six months later, she presented again complaining of tiredness, paresthesia in the lower limbs, and persistence of the oral lesions. The laboratory work-up revealed macrocytic anemia with a normal reticulocyte count, pancytopenia, and increased lactate dehydrogenase and indirect bilirubin. The findings of positive intrinsic factor antibody titers confirmed the diagnosis of pernicious anemia. The patient was prescribed intramuscular hydroxocobalamin (1000 g/d for 7 days, followed by 1000 g/wk for 4 weeks). The oral lesions resolved after 1 month of treatment (Fig. 1B), and her complete blood count was within normal values. The patient continued to receive monthly injections of hydroxocobalamin. Pernicious anptemia is the deficiency of cobalamin caused by intrinsic factor antibodies, which interfere with its absorption and lead to ineffective erythropoiesis. Oral abnormalities such as glossitis, papillary atrophy, erythematous macules, angular cheilitis, and burning tongue pain

Burning Erythematous Oral Macules as the Presenting Manifestation of Vitamin B12 Deficiency