English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Exploring novel regimens is essential to ensure the efficacy of paclitaxel-based chemotherapy in epithelial ovarian cancer.  Brucea javanica  (L.) Merr., Simaroubaceae, oil emulsion benefits the patients who received sequential chemotherapy, and bruceine D is identified as the major active tetracyclic quassinoid. On this premise, we explored the potential effects and related molecular mechanisms of bruceine D on epithelial ovarian cancer cells. Our study indicated an inhibitory effect of bruceine D treatment in epithelial ovarian cancer cells. Increased cell apoptosis and cancer stem cell elimination were observed with combined treatment of bruceine D and paclitaxel in ovarian cancer cells. Mechanism study indicated that JNK and STAT3 signaling regulation contributed to the synergistic effects of bruceine D in paclitaxel-based chemotherapy. Our study revealed a synergistic effect of bruceine D in paclitaxel-based chemotherapy. Our investigation provided a valuable strategy to enhance the efficiency of chemotherapy in ovarian cancer. Graphical abstract

Bruceine D Sensitizes Human Ovarian Cancer Cells to Paclitaxel Through JNK and STAT3 Signal Regulation