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Cyberphysical microelectrode-dot-array (CP-MEDA)-based digital microfluidic biochip (DMFB) is attracting more attention than its predecessor of traditional DMFB. Conventional DMFBs are mostly unable to recover from the errors incurred at assay run time, and thus, it leads to unacceptable results. Recent studies have revealed the vulnerability of CP-DFMBs to detect malicious intrusions during its design or operational phase. In this paper, we have analysed such vulnerable scenarios that have been utilized by the routing-based-synthesis approach on a CP-MEDA. We have also depicted the mixing operations based on routing for ensuring better security measures. Various attacking scenarios have been demonstrated on a MEDA-based DMFB, and moreover, checkpoint-based intrusion detection method has been proposed for the RBS technique. The effectiveness of our approach is compared with the available benchmark assays. Our proposed method has shown significant improvement over the existing state-of-the-art procedures in terms of assay execution time and intrusion detection rate.

Security assessment for routing-based synthesis on cyberphysical MEDA-based digital microfluidic biochip