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The ever-increasing supply of information combined with the growing knowledge elicitation capabilities of key emerging technologies presents pharmacovigilance with enormous opportunities. Currently, safety monitoring is expanding its evidence base, moving beyond traditional approaches towards sophisticated methods that can identify possible safety signals from multiple information sources, both structured and unstructured. In this context, health information posted online by patients represents a potentially valuable, yet currently left largely unexploited source of post-market safety data that could supplement data from traditional sources of drug safety information. As the use of social media data for pharmacovigilance is still in its infancy, the present paper explores the state of the art in the application of social data to adverse drug reaction detection; provides a thorough review of existing work in the field, highlighting important research efforts and achievements; and finally, discusses the current challenges and promising avenues for future work. Following a literature review methodology, a critical appraisal was conducted of carefully selected work on the use of social data in post-market surveillance, as presented in the recent scientific literature. Out of a sample of more than 1300 articles, which was the result of the literature search, the final selection of articles was made based on their relevance to the applications of social networking sites (SNS) to pharmacovigilance, and a thorough review of this corpus was completed with a total of 100 articles reviewed. The main contributions of this review include the mapping and systematisation of the current knowledge in the field by drawing comparisons of different approaches, types of social data and of relevant sources currently used in the field, and by developing new classifications of social data sources and taxonomies for social data for use in pharmacovigilance, as well as the identification of key challenges and the extraction of new insights in terms of potential for practical applications and future research directions in the area of pharmacovigilance.

Harnessing social media data for pharmacovigilance: a review of current state of the art, challenges and future directions