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In pediatric patients with asthma, measurements of forced expiratory volume in 1 s (FEV 1 ) may be normal or may not correlate with symptom severity. Forced expiratory flow at 25-75% of the vital capacity (FEF 25-75% ) is a potentially more sensitive parameter for assessing peripheral airway function. This post hoc analysis compared FEF 25-75% with FEV 1 as an endpoint to assess bronchodilator responsiveness in children with asthma.

pulmonary therapy

Forced Expiratory Flow (FEF25–75%) as a Clinical Endpoint in Children and Adolescents with Symptomatic Asthma Receiving Tiotropium: A Post Hoc Analysis