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HighlightsFactors affecting microneedle insertion into skin are reviewed.    The use of artificial and computational skin models for the simulation of needle insertion is summarized.    Skin structures and models, as well as mechanical analyses, used to determine transdermal microneedle ability to insert into skin are highlighted in the review.

Engineering Microneedle Patches for Improved Penetration: Analysis, Skin Models and Factors Affecting Needle Insertion