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HighlightsNb 2 C and Ta 2 C MXenes exhibit remarkable SERS performance with the enhancement factors of 3.0 × 10 6  and 1.4 × 10 6 , which is synergistically enabled by the PICT resonance enhancement and electromagnetic enhancement.    The excellent SERS sensitivity endows Ta 2 C MXene with the capability to sensitively detect and accurately identify the SARS-CoV-2 spike protein, which is beneficial to achieve real-time monitoring and early warning of novel coronavirus.Electronic supplementary material  The online version of this article (10.1007/s40820-020-00565-4) contains supplementary material, which is available to authorized users.

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Charge-Transfer Resonance and Electromagnetic Enhancement Synergistically Enabling MXenes with Excellent SERS Sensitivity for SARS-CoV-2 S Protein Detection