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Epigenetic mechanisms are of interest as therapeutic targets in photocarcinogenesis as they are reversible. Evidence derived from mouse models of ultraviolet radiation-induced skin carcinogenesis and other photocarcinogenesis models suggests that these changes can be controlled or prevented by phytochemicals derived from dietary plants. Thus, improved knowledge of the potential effects of green tea polyphenols (GTPs) and proanthocyanidins from grape seeds (GSPs) on epigenetic processes may be useful for the chemoprevention of skin cancers which are a major public health concern. In the present article, we provide a short review of epigenetic regulatory mechanisms in mammals and examine the impact of two natural substances, GTPs, and GSPs, on these epigenetic processes.

Epigenetic Regulation by Dietary Phytochemicals in Photocarcinogenesis