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Instrumental variable (IV) methods continue to be applied to questions ranging from genetic to social epidemiology. In the epidemiologic literature, discussion of whether the assumptions underlying IV analyses hold is often limited to only certain assumptions and even then, arguments are mostly made using subject matter knowledge. To complement subject matter knowledge, there exist a variety of falsification strategies and other tools for weighing the plausibility of the assumptions underlying IV analyses.

Understanding the Assumptions Underlying Instrumental Variable Analyses: a Brief Review of Falsification Strategies and Related Tools