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This review aims to discuss the methodological aspects of dedicated molecular breast imaging (MBI) using 99m Tc-sestamibi as radiotracer to guide biopsy of occult or unclear breast lesions on mammography (MG) and ultrasound (US) that are suspicious on MBI (BI-RADS criteria 4 and 5), including its advantages, limitations and future clinical applications.

Methodological aspects of 99mTc-sestamibi guided biopsy in breast cancer