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A novel modelling technique using finite element analysis to mimic themechanoresponse of cell-laden biomaterial is proposed for the use in bioinksand other tissue engineering applications. Here a hydrogel-based compositebiomaterial specimen was used consisting of 5% (V/V) HeLa cells added toalginate solution (4% W/V) and another specimen with no living cell present inalginate solution (4% W/V). Tensile test experiments were performed on both thespecimens with a load cell of 25 N. The specimens were bioprinted using anin-house developed three-dimensional (3D) bioprinter. To allow for thenonlinear hyperelastic behavior of the specimen, the specimens were loaded veryslowly, at rates of 0.1 mm/min and 0.5 mm/min, during the tensile test. Themicroscale finite element models developed in Ansys were loaded with similarload rates and their responses were recorded. Both the model results werevalidated with the experiment results. A very good agreement between the finiteelement model and the tensile test experiment was observed under the samemechanical stimuli. Hence, the study reveals that bioprinted scaffold can bevirtually modeled to obtain its mechanical characteristics beforehand.

Cell-Laden alginate biomaterial modelling using three-dimensional (3D) microscale finite element technique