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International audienceStrontium (Sr) compds. have become increasingly popular in the field of osteoporosis treatment. However, the quality of new bone after implantation of strontium-contg. bioceramics has yet to be investigated. In the present study, the newly formed bone tissue around strontium-doped bioactive glass (BG-Sr) implants was characterized. BG-Sr was implanted in the femoral condyl of ovariectomized rats (OVX). The resected bone was prepd. for anal. using several physico-chem. and biol. assays such as Fourier transform IR spectroscopy, X-ray diffraction, SEM, energy-dispersive X-ray, and histomorphometry. BG-Sr biomaterial favored calcium phosphate layer integration on the surface of the glass and offered better bioactivity. Moreover, the histomorphometric anal. demonstrated that BV/TV, N. Ob were significantly higher in BG-Sr treated rats groups than those of BG groups. However, Ob. S/BS, and OV/BV were significantly lower in BG-Sr treated rats groups than those of BG groups. The (Oc.S/ BS) was significantly decreased in BG-Sr groups, when compared with that of BG rat groups. On the other hand, the MS/BS had not significantly decreased in the BG-Sr treated rats groups when compared with that of BG groups, however; it was significantly higher when compared with control and OVX groups. These findings suggest that BG-Sr can be used as an inhibitory therapeutic potential of osteoporosis by delivering strontium to stimulate new bone remodeling. [on SciFinder(R)

han'gug eung'yong saengmyeong hwa haghoeji/journal of the korean society for applied biological chemistry

The potential restorative effects of strontium-doped bioactive glass on bone microarchitecture after estrogen-deficieny induced osteoporosis: Physicochemical and histomorphometric analyses