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Three new  ent -kauranoids, isorosthornins A-C ( 1–3 ), and a new natural product, dihydroponicidin ( 4 ), together with five known ones were isolated from the aerial parts of  Isodon rosthornii . The structures were determined by means of extensive spectroscopic analysis. All diterpenoids isolated were evaluated for their cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW480 cell lines, and compounds  5  and  7  showed significant inhibitory effects on all cell lines.Electronic Supplementary Material  Supplementary material is available for this article at 10.1007/s13659-011-0031-7 and is accessible for authorized users.

Isorosthornins A-C, new ent-kaurane diterpenoids from Isodon rosthornii