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We assessed firing and voltage-gated Ca 2+ influx in medial prefrontal cortex (mPFC) pyramidal neurons from older (12 months old) HIV-1 transgenic (Tg) rats. We found that neurons from older Tg rats showed increased firing compared to non-Tg rats, but Ca 2+ spikes were unchanged. However, stronger excitatory stimulation was needed to evoke Ca 2+ spikes, which was associated with reduced mPFC Ca v 1.2 L-type Ca 2+ channel (L-channel) protein. In contrast, L-channel protein was unaltered in younger (6-7 weeks old) Tg rats, which we previously found had enhanced neuronal Ca 2+ influx. These studies demonstrate that aging alters HIV-induced Ca 2+ channel dysfunction that affects mPFC activity.

Aging alters voltage-gated calcium channels in prefrontal cortex pyramidal neurons in the HIV brain