English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The 23rd Sanibel Conference, sponsored by the American Society for Mass Spectrometry, was held January 21– 24, 2011, at the TradeWinds Island Grand Hotel, St. Pete Beach, Florida. The topic of this year was “From Fragmentation Mechanisms to Sequencing: Tandem Mass Spectrometry-Based Peptide and Protein Identification.” The conference was co-organized by Béla Paizs, German Cancer Research Center, Heidelberg, Germany, and Matthias Mann, Max-Planck Institute of Biochemistry, Martinsried, Germany. A key information unit in the use of tandem mass spectrometry (MS/MS) in proteomics is the product-ion spectrum of peptides or intact proteins. Most of the basic biological and clinical investigations in proteomics face the problem of peptide or protein sequencing by using raw MS/MS data. The current data-processing strategies apply both fragmentation models that describe how peptides or proteins fragment in mass spectrometers and various bioinformatics strategies that attempt to derive the sequences from the raw spectral data based on these fragmentation models. It is widely accepted in the proteomics community that robust peptide and protein sequencing requires further improvement in fragmentation models and bioinformatics tools. Historically, peptide fragmentation chemistry and bioinformatics approaches to sequencing have been developed by their respective, distinct communities, with limited interaction between them. This is despite both communities working towards the same goal; the development and implementation of an accurate peptide and protein sequencing strategy. As a direct result of this parallel and independent development, recent mechanistic insights into peptide fragmentation are seldom incorporated into the most popular peptide identification or sequencing algorithms. These software packages are mainly based on peptide fragmentation models developed in the mid 1990s. The purpose of the 23 Sanibel conference was to bring the peptide fragmentation and bioinformatics communities closer to each other by offering a forum to create a common language, exchange ideas, and establish joint research projects. This initiative was well-appreciated by the community, and the conference attracted a record attendance in the history of Sanibel meetings with 200 participants presenting 27 invited lectures and submitting 77 poster abstracts. The conference opened with a general introductory talk by Matthias Mann (Max-Planck Institute of Biochemistry, Martinsried) on Friday evening, followed by a reception. This overview demonstrated that MS-based proteomics has become an extremely powerful tool for biological and medical research, with applications ranging from deep protein expression studies, modification analysis, interaction mapping, to even clinical applications. Saturday started with an overview of basic fragmentation chemistry and sequencing strategies given by Béla Paizs (German Cancer Research Center, Heidelberg), attempting to bridge the two communities and to define a common language. Sessions discussing the chemistries of collisioninduced dissociation and electron capture/transfer dissociation made up the rest of the day, with presentations by Simon Gaskell (Queen Mary University of London, London, UK), Gary Glish (University of North Carolina, Chapel Hill), Gavin Reid (Michigan State University, East Lansing),

journal of the american society for mass spectrometry

23rd Sanibel Conference on Mass Spectrometry: From Fragmentation Mechanisms to Sequencing: Tandem Mass Spectrometry Based Peptide and Protein Identification