Open AccessThe immunology connection—my first T cell receptor structure projects
Author(s) -
JiaHuai Wang
Publication year - 2014
Publication title -
protein and cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.973
H-Index - 63
eISSN - 1674-8018
pISSN - 1674-800X
DOI - 10.1007/s13238-014-0091-7
Subject(s) - national laboratory , t cell receptor , developmental biology , biology , library science , immunology , engineering , computer science , engineering physics , microbiology and biotechnology , t cell , immune system
Ellis Reinherz and I were riding in a luxury Boston Coach to Long Island in New York State driven by a professional driver. This was not a vacation trip to one of the best leisure places in the United States. We were heading toward the National Laboratory at Brookhaven, where a powerful X-ray source is available in a facility called a synchrotron. The aim of our trip was to use a strong X-ray to shoot the crystals of the T cell receptor (TCR) we had just managed to grow after considerable effort for three-dimensional structure determination. In 1996, this was one of the hottest projects in structural biology as well as in immunology.
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