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Extra skeletal Ewing’s sarcoma (EES) is an uncommon, rapidly growing, and round-cell malignancy of uncharacterized mesenchymal cell origin. The extra skeletal forms usually occur in the soft tissue of lower extremities, para vertebral tissues, chest wall, and retro peritoneum. Extra osseous ES are uncommon, with occasional reports of tumors affecting the genitourinary tract. Only few cases of primary vaginal Ewing’s sarcoma have been previously reported in the literature (only 22 cases). Ewing sarcoma (ES) and Primitive Neuroectodermal Tumor (PNET) family of tumors were classified differently in the past. But now due to their common molecular and clinical features they are considered as single tumor category known as Ewing family of tumors (EFTs) [1]. More than 90 % of these tumors contain Ewing Sarcoma RNAbinding protein 1(EWSR1)-FLI1fusion protein due to t (11; 22) (q24; q12) chromosomal translocation.

Primary Vaginal Ewing’s sarcoma: A Rare Case Report