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Background Family with sequence similarity 65 member A (FAM65A), also known as RIPOR1, is differentially expressed between human tumor and non-tumor tissues in kinds of cancers. In addition, it was reported that the product of  FAM65A  may be a biomarker for cholangiocarcinoma patients. However, there is still no evidence on the relationship between the  FAM65A  and different types of tumors. Our study is mainly for exploring the prognostic values of  FAM65A  in pan-cancer and for further discovering a potential therapeutics target. Methods We analyzed  FAM65A  expression, prognostic values, genetic alteration, protein phosphorylation, immune infiltration and enrichment analysis across different types of human malignant tumors based on The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets. Additionally, Real-Time PCR (RT-qPCR) was performed to further confirm the roles of  FAM65A  in the pathogenesis of colorectal cancer. Results We found that  FAM65A  expression was associated with the prognosis of multiple human tumors, especially colorectal cancer. Moreover, we also observed that  FAM65A  was highly expressed in colorectal cancer through RT-qPCR. We observed that decreasing phosphorylation level of the S351 locus in colon adenocarcinoma, uterine corpus endometrial carcinoma and lung adenocarcinoma. And the expression of  FAM65A  was positively related to cancer-associated fibroblasts (CAFs) infiltration in many tumors, such as colon adenocarcinoma. Therefore,  FAM65A  may be a potential prognostic biomarker of human tumors.

FAM65A as a novel prognostic biomarker in human tumors reveal by a pan-cancer analysis