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Three trials were conducted to evaluate the therapeutic efficacy of closantel (@ 7.5 mg/kg body weight, orally), fenbendazole (@ 7.5 mg/kg body weight, orally) and ivermectin bolus (@ 0.2 mg/kg body weight, orally) against gastrointestinal (GI) helminth parasites of cattle in central zone of Kashmir valley. Twenty cattle suffering from GI helminth infection were randomly selected and divided into two groups in each trial. In each trial, one group comprising of fifteen animals were treated with anthelmintic and second group comprising of five animals were kept as infected untreated control. To determine the therapeutic efficacy of different anthelmintic drugs against GI helminths, faecal samples were directly collected from rectum before treatment and on 7th, 14th and 28th day post treatment and eggs per gram of faeces was determined by using Stoll's method. Then the efficacy of different anthelmintics was calculated by employing Faecal Egg Count Reduction Test. On 14th day post treatment closantel was found to be 100 and 94.44% effective against Fasciola spp. and strongyle worms, respectively, however, it was not found effective against Trichuris spp. The efficacy of fenbendazole was 100% against Fasciola spp., paramphistomes, Moniezia spp., Trichuris spp. and strongyle worms on 14th day post treatment. Ivermectin was found to be 100% effective against Trichuris spp. and strongyle worms on 14th day post treatment, however, it was not effective against Fasciola spp. and paramphistomes.

Efficacy of closantel, fenbendazole and ivermectin against GI helminths of cattle in central Kashmir