English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

In recent decades, the incidence of metabolic disorders has increased internationally. This increase has been linked to exposure to persistent organic pollutants (POPs), but little is known about the metabolic effects of realistic human exposure mixtures at relevant concentrations. In this study we tested if POPs, representing real-life exposure profiles and concentrations, were able to disrupt development and functions of adipose tissue in a direct way. The lipogenic potency of a POP mixture modelled on levels found in human blood as detected in the Scandinavian population was assessed. The Total mixture comprises 29 compounds divided over three groups: chlorinated (Cl), brominated (Br) and perfluorinated compounds (PFAA). Individual PFAA chemicals, the Total mixture and sub-mixtures (Cl, Br, PFAA, Cl + Br, Cl + PFAA and Br + PFAA) at five (× 1/10, × 1, × 50, × 100 and × 500) human blood levels were tested in an optimized high content analysis (HCA) 3T3-L1 adipogenesis assay. All exposures promoted adipocyte formation in 3T3-L1 cells at concentrations equivalent to × 1/10 human blood levels. PFAAs promoted lipid accumulation in 3T3-L1 cells at 33.6 pM (PFUnDA) and 390,460 pM (PFHxS). The Total mixture, and the Cl, PFAA, Cl + Br and Cl + PFAA sub-mixtures, started to promote lipid accumulation at × 1/10 human blood levels. This in vitro bioassay study assessed the adipogenic effects of POP mixtures modelled on real-life human exposure levels. The findings highlight that such exposures may alter adipose tissue development and function, thus potentially playing a role in the globally increasing escalation of metabolic disorders.

exposure and health

Lipogenic Potency of Individual Perfluorinated Alkyl Acids (PFAAs) and Persistent Organic Pollutant (POP) Mixtures at Human Blood-Based Exposure Levels on Adipogenesis in 3T3-L1 Cells