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Imaging Somatostatin Subtype Receptor 2 (SST 2 ) expressing macrophages by [DOTA,Tyr 3 ]-octreotate (DOTATATE) has proven successful for plaque detection. DOTA-JR11 is a SST 2 targeting ligand with a five times higher tumor uptake than DOTATATE, and holds promise to improve plaque imaging. The aim of this study was to evaluate the potential of DOTA-JR11 for plaque detection.

Imaging inflammation in atherosclerotic plaques, targeting SST2 with [111In]In-DOTA-JR11