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Mitochondria contain an organellar genome that encodes for subunits of the respiratory chain. Its coordinated expression is essential for eukaryotic life and defects in this process lead to severe disease. However, the molecular mechanisms underlying mitochondrial gene expression remain poorly understood. Recent structural and functional studies have provided the first mechanistic insights into mitochondrial gene expression and highlight the evolutionarily unique nature of this system.

Mitochondrien: wie die Gene im Kraftwerk der Zelle aktiviert werden