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The growing demand of blood products in modern medicine causes chronic limitations in blood supply. Current research focuses on the  ex vivo  production of red blood cells (RBCs) from different sources including induced pluripotent stem cells (iPSCs). RBC generation from iPSCs is limited by low effciency so far. Our group established a protocol that enables for higher cellular output and improved enucleation based on closer mimicking of the physiological microenvironment in which erythropoiesis occurs.

Ex vivo-Expansion von roten Blutzellen aus humanen Stammzellen