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Requirement of a dopaminergic neuronal phenotype for toxicity of low concentrations of 1-methyl-4-phenylpyridinium to human cells. Toxicol Appl Pharmacol 241:23–35 [2] Scholz D, Pöltl D, Genewsky A et al. (2011) Rapid, complete and large-scale generation of post-mitotic neurons from the human LUHMES cell line. Neuroprotection by minocycline caused by direct and specific scavenging of peroxynitrite. Generation of genetically-modified human differentiated cells for toxicological tests and the study of neurodegenerative diseases. ALTEX 30:427–444 [5] Schildknecht S, Gerding HR, Karreman C et al. (2013) Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies. and metabolic adaptation of human neurons to the mitochon-drial toxicant MPP(+).dation zum stabilen MPP + umgewandelt.

Etablierung von LUHMES als Zellmodell menschlicher Dopamin-Neurone