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Dear Editor,A few studies have focused on exploring APOE generelated effects on cognitive functions and brain activities in healthy populations.Bondi et al.found thate4 carriers perform significantly worse on the California Verbal Learning Test than non-carriers in non-demented old subjects(mean age,72 years)[1].B ut the results are not entirely consistent.For example,Scarmeas et al.found no effect of thee4 allele on neuropsychological performance[2]in young adults,and Jochemsen et al.found that thee4allele is associated with age-related cognitive decline[3].Furthermore,protective and negative effects of thee2allele on cognition are inconsistent[4,5].APOEe2 is thought

Apolipoprotein E gene polymorphisms associated with processing speed and executive functions in healthy Han Chinese