English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The global prevalence of obesity is increasing across all age groups and in both sexes, contributing to the early emergence of insulin resistance usually followed by the development of type 2 diabetes (Kahn and Flier 2000; Reaven 1995). The pathology is determined by resistance to insulin action in multiple tissues, accompanied by failure of pancreatic β-cells to compensate the lack of response through increased insulin synthesis and secretion, a condition that leads to β-cell damage (Graham and Kahn 2007). Obesity in humans appears to be mostly related to complex interactions between genetic and environmental factors. Although diet affects the function of several somatic cell types playing a key role also in diseases like obesity and diabetes, it is widely accepted that none of the somatic cell effects can be transmitted to the next generation. The majority of environmental factors does not alter the animal’s DNA sequence, but rather promote alterations that can influence somatic cell metabolism, and therefore the health status of the individual exposed to them. In the current paradigm for disease etiology, either single-nucleotide polymorphisms (SNiPs) or chromosomal abnormalities can promote the onset of a disease; however, evidences are accumulating in the last years that also the environment is equally important in disease etiology.

A sideways glance: Lamarck strikes back? Fathers pass on to progeny characteristics they develop during their lives