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One challenge in the surgical management of breast cancer is maximizing the preservation of healthy tissue while achieving acceptable negative margins. Tools capable of assessing disease-margin involvement intraoperatively and in real-time could provide clinically useful guidance regarding the adequacy of margin resection before the surgery is over. Here we report the intraoperative use of optical coherence tomography (OCT) in 3 patients with DCIS. In all 3 cases, additional lesions identified by OCT during surgery were also noted in histopathology reports 3 to 5 days post-surgery, suggesting that intraoperative use of OCT is a valuable  tool for margin determination in real-time.

indian journal of surgery

Potential Utility of Adjunct Imaging with Wide-Field Optical Coherence Tomography for Gross and Microscopic Evaluation of Breast Specimens in Real-Time in the Operating Suite