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In recent years, resistance to chemical antibiotics, as well as their side effects, has caused a necessity to utilize natural substances and herbal components with antibacterial effects. Curcumin, the major substance of  Curcuma longa ’s rhizome, was used as an antibacterial agent since ancient times. This work aimed to formulate a novel nanocomposite for the delivery of curcumin to overcome orthodox drugs resistance against bacteria and improve its efficacy. To fabricate targeting nanocomposites, first, Fe 3 O 4  nanoparticles were synthesized followed by coating the obtained nanoparticles using sodium alginate containing curcumin. A 2 by 3 factorial design was tailored to predict the optimum formulation of nanocomposites. Characterization of nanocomposites including particle size, polydispersity index (PDI), zeta potential, entrapment efficiency, and drug loading was performed. The optimum formulation was analyzed by differential scanning calorimetry (DSC), scanning electron microscopy (SEM), Fourier-transformed infrared spectroscopy (FT-IR), and in vitro release study at different pHs. Finally, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of samples against seven common bacteria were determined. Results showed that the optimized formulation contained 400 nm particles with the PDI and zeta potentials of 0.4 and − 58 mV, respectively. The optimized formulation with 70% entrapment efficiency reduced the MIC value 2 to 4 times in comparison with pure curcumin. Results also showed that polymer and drug concentrations can significantly affect entrapment efficiency. In conclusion, the current investigation demonstrated that this magnetic nanocomposite can be applied for the delivery of curcumin. Graphical abstract

Improving Antibacterial Efficiency of Curcumin in Magnetic Polymeric Nanocomposites