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Around the beginning of the 2021 new year, Europe's COVID-19 third wave led many leaders to implement a new lockdown period, with the teaching-learning system returning to the online method once more. The present study aimed to understand the health consequences for adolescents and young adults (AYA) during the third wave's lockdown. This mixed-method study included 592 participants between 16 and 24 years old ( M  = 19.01, SD  = 2.32), with the majority being female (70.9%) and students (82.3%) at high school (55.1%) or university (44.9%). Negative impacts are highlighted in the categories: relationships, physical activity (as well aseno impacts), screen time and academic stress; and no impactsin health and well-being, leisure activities, sleep, diet, academic performance and relationships with teachers and peers. Overall, when compared to the opposite gender, girls report more negative impacts on leisure activities and diet, although more positive impacts on diet, as well as on academic stress; boys stand out in the negative consequences on substance use. At the academic level, students in higher education show more negative impacts on relationships, leisure activities, sleep, diet, screen time and relationships with teachers and peers. Enlightened about the impacts of the second lockdown on their lives, and showing signs of "pandemic fatigue", this study draws attention to the need to associate psychological support measures with those implemented to contain the COVID-19 pandemic.

COVID-19 Pandemic and the Second Lockdown: The 3rd Wave of the Disease Through the Voice of Youth