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Among different PET tracers, 18 F-fludeoxyglucose (FDG) and 11 C-choline are known to have a high tumor uptake correlated with a high mitotic index of tumor cells. Thus, the uptake of 18 F-FDG and 11 C-choline may be dependent on the cell cycle. In the present study, we examined the uptake of 18 F-FDG and 11 C-choline in cancer cell lines by cell cycle synchronization to clarify the biological properties of cancer cells with respect to each tracer.

18F-FDG and 11C-choline uptake in proliferating tumor cells is dependent on the cell cycle in vitro