Open AccessThyroid hormone deiodinases response in brain of spontaneausly hypertensive rats after hypotensive effects induced by mandibular extension
Author(s) -
Laura Sabatino,
Giuseppe Federighi,
Cristina Del Seppia,
Dominga Lapi,
Chiara Costagli,
Rossana Scuri,
Giorgio Iervasi
Publication year - 2021
Publication title -
endocrine
Language(s) - English
Resource type - Journals
eISSN - 1559-0100
pISSN - 1355-008X
DOI - 10.1007/s12020-021-02684-3
Subject(s) - dio2 , endocrinology , medicine , hormone , thyroid , blood pressure , thyroid hormones , deiodinase
The deiodinases activate or inactivate the thyroid hormones (TH) in virtually all tissues in both physiological and pathological conditions. The three deiodinases, DIO1, DIO2, and DIO3, have different catalytic functions and regulate TH tissue distribution. The aim of the present study was to evaluate the modulation of gene expression of the deiodinases and TH transporters and protein levels of DIO1 in parietal and frontal areas of cerebral cortex of spontaneously hypertensive rats (SHRs), after two successive mandibular extensions (ME).
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