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18 F-FDG thyroid incidentaloma (TI) occurs in ~2% of PET/CT examinations with a cancer prevalence of up to 35-40%. Guidelines recommend fine-needle aspiration cytology (FNA) if a focal 18 F-FDG TI corresponds to a sonographic nodule &gt;1 cm. The aim of this systematic review and meta-analysis was to provide evidence-based data on the diagnostic distribution of 18 F-FDG TIs in the six Bethesda systems for reporting thyroid cytopathology (BETHESDA) subcategories.

The dilemma of 18F-FDG PET/CT thyroid incidentaloma: what we should expect from FNA. A systematic review and meta-analysis