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After more than five decades of research, the failure of bone implants isstill an issue that becomes increasingly urgent to solve in our ageingpopulation. Among the reasons for failure, catastrophic brittle fracture is oneevent that is directly related to the implant s material and fabrication andthat deserves more attention. Indeed, clinically available implants pale atreproducing the hierarchical and heterogeneous microstructural organization ofour natural bones, ultimately failing at reproducing their mechanical strengthand toughness. Nevertheless, the recent advances in additive and advancedmanufacturing open new horizons for the fabrication of biomimetic boneimplants, challenging at the same time their characterization, testing andmodelling. This critical review covers selected recent achievements in boneimplant research from a materials standpoint and aims at deciphering some ofthe most urgent issues in this multidisciplinary field.

A materials perspective on the design of damage-resilient artificial bones and bone implants through additive/advanced manufacturing