English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Obstructive sleep apnea (OSA) is an increasingly common disorder associated with increased cardiovascular disease, mortality, reduced productivity, and an increased risk of road traffic accidents. A significant proportion of patients with OSA in the UK are undiagnosed. This study aims to identify risk factors for OSA in an obese cohort.    Method  A population-based study was conducted of obese patients (BMI ≥ 30 kg/m 2 ) from the Clinical Practice Research Datalink (CPRD). A logistic regression model was used to calculate odds ratios (ORs) for developing OSA according to other clinicopathological characteristics. Multivariate analysis was conducted of individual factors that affect the propensity to develop OSA. Statistical significance was defined as  p  < 0.050.    Results  From 276,600 obese patients identified during a data extraction of the CPRD in July 2017, the prevalence of OSA was 5.4%. The following risk factors were found to be independently associated with increased likelihood of OSA: male sex (OR = 3.273;  p  < 0.001), BMI class II (OR = 1.640;  p  < 0.001), BMI class III (OR = 3.768;  p  < 0.001), smoking (OR = 1.179;  p  < 0.001), COPD (OR = 1.722;  p  < 0.001), GERD (OR = 1.557;  p  < 0.001), hypothyroidism (OR = 1.311;  p  < 0.001), acromegaly (OR = 3.543;  p  < 0.001), and benzodiazepine use (OR = 1.492;  p  < 0.001). Bariatric surgery was associated with reduced risk of OSA amongst this obese population (OR = 0.260;  p  < 0.001).    Conclusions  In obese patients, there are numerous comorbidities that are associated with increased likelihood of OSA. These factors can help prompt clinicians to identify undiagnosed OSA. Bariatric surgery appears to be protective against developing OSA.

Obstructive Sleep Apnea in Obese Patients: a UK Population Analysis