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Atrial fibrillation (AF) is the most common arrhythmia affecting millions ofpeople in the Western countries and, due to the widespread impact on thepopulation and its medical relevance, is largely investigated in both clinicaland bioengineering sciences. However, some important feedback mechanisms arestill not clearly established. The present study aims at understanding theglobal response of the cardiovascular system during paroxysmal AF through alumped-parameter approach, which is here performed paying particular attentionto the stochastic modeling of the irregular heartbeats and the reducedcontractility of the heart. AF can be here analyzed by means of a wide numberof hemodynamic parameters and avoiding the presence of other pathologies, whichusually accompany AF. Reduced cardiac output with correlated drop of ejectionfraction and decreased amount of energy converted to work by the heart duringblood pumping, as well as higher left atrial volumes and pressures are some ofthe most representative results aligned with the existing clinical literatureand here emerging during acute AF. The present modeling, providing new insightson cardiovascular variables which are difficult to measure and rarely reportedin literature, turns out to be an efficient and powerful tool for a deepercomprehension and prediction of the arrythmia impact on the wholecardiovascular system.

Impact of atrial fibrillation on the cardiovascular system through a lumped-parameter approach