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Revealing the behavior of single molecules in single live cells provides a fundamental approach to understand cellular organization and dynamics. With the rapid merging of biotechnology and nanotechnology in recent years, single plasmonic nanoparticle sensors have endowed a new dimension to the imaging scale given their comparable size to biomolecules such as nucleic acids or antibodies. Single-particle method thus presents a promising tool for interrogating how biological events occur at the single-molecule level both in vitro and in vivo. These new technological developments will drive the discovery of new principles of cellular and molecular biology, and set the stage for developing clinical applications in the near future. During the past decade, we have also seen rapid rise in bioimaging research in China. In this special topic for “Sin-

Special topic for “single-molecule, single-particle and single-cell bioimaging”