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COVID-19 has caused huge impacts on human health and the economic operation of the world. Analyzing and summarizing the early propagation law can help reduce the losses caused by public health emergencies in the future. Early data on the spread of COVID-19 in 30 provinces (autonomous regions and municipalities) of mainland China except for Hubei, Hong Kong, Macao, and Taiwan were selected in this study. Spatio-temporal analysis, inflection point analysis, and correlation analysis are used to explore the spatio-temporal characteristics in the early COVID-19 spread. The results suggested that (1) the total confirmed cases have risen in an "S"-shaped curve over time, and the daily new cases have first increased and finally decreased; (2) the spatial distributions of both total and daily new cases show a trend of more in the east and less in the west, with a "multi-center agglomeration distribution" around Hubei Province and some major cities; (3) the spatial agglomeration of total confirmed cases has been increasing over time, while that of the daily new cases shows much more obvious in the mid-stage; and (4) timely release of the first-level public health emergency response can accelerate the emergence of the epidemic inflection point. The above analysis results have a specific reference value for the government's policy-making and measures to face public health emergencies.

Spatio-temporal characteristics and control strategies in the early period of COVID-19 spread: a case study of the mainland China